Karen Gardeazabal was born in Toluca and studied in Mexico City. She continued her education in the UK in 2011 and four years later she attended the International Opera Performing Experience in Italy. She has been a student of top opera stars like Ramón Vargas and Plácido Domingo. She won several prizes including the Carlo Morelli Award at Palacio de Bellas Artes in Mexico and the Jeunes Ambassadeurs Lyriques.

Gardeazabal has performed as Mimi (La Bohème) at the Festival Euro Mediterraneo in Taormina that was aired in international movie theatres. Other roles include Adina (L’Elisir D’Amore), Elcía (Cosí Fan Tutte) for New Opera Theatre in Dubai, Fiordiligi (Cosí Fan Tutte), Tebaldo (Don Carlo) along with Plácido Domingo and María José Siri for Palau de les Arts.

Recently she also performed as Mimi (La Bohème) at Teatro di San Carlo in Naples and made her debut at Arena di Verona as Frasquita and Micaela in Carmen.

In October 2019 she toured Mexico with Javier Camarena.